Which assessment finding is expected in a patient with multiple sclerosis (MS)
Abstract[edit | edit source]The purpose of this case study is to illustrate important clinical findings in an active patient recently diagnosed with relapse-remitting multiple sclerosis (RRMS) and suggest an evidence-based management plan to address the patient’s participation restriction. The patient presents with decreased upper extremity coordination, upper extremity weakness, fatigue, impaired balance, and dexterity dysfunction. These clinical characteristics have led to decreased participation in her hobbies as well as occupational productivity, having substantial impact on her physical and mental state. The interventions suggested included balance training, coordination and dexterity training, and self-management. Baseline measures of her functional capacity were taken during initial assessment using self-reported and clinician-reported outcome measures. The outcome measures used included UEFS, FSMC, MSIS-29, six-minute walk test, and the nine hole peg test, which were reassessed 8 weeks later. Show
Introduction[edit | edit source]Multiple sclerosis (MS) is a neurological condition characterized by inflammatory demyelination over multiple episodes and locations in the central nervous system[1]. The complex nature of MS, its variance among patients, unpredictability, and potential to create a heavy social and emotional burden on patients can make appropriate, effective management challenging for community physiotherapists[1]. The debilitating symptoms (fatigue, arm movement and/or vision problems, ambulatory impairment, etc[1]) can considerably impact patients’ ability to fulfill their occupational, familial, and community roles. The purpose of the present fictional case is to illustrate the clinical presentation of MS and propose appropriate, evidence-based management interventions that effectively address participation restrictions of an active patient. Case:[edit | edit source]A 29 year-old graphic designer, Betty Jackson first noticed her symptoms in the summer of 2019 while she was biking along the lake with her husband. She was experiencing difficulty reading signage and clumsiness using her arms while steering her bike. Upon completing her route, she felt excessively fatigued. These symptoms persisted for a few days, eventually affecting her productivity at work, prompting a visit to her family physician. MRI findings revealed demyelination and plaques in the corpus callosum; the physician classified her event as a “clinically isolated syndrome” of MS[1]. Approximately 10 months later, Betty’s symptoms resurfaced: she experienced the same fatigue, vision disturbances and arm issues. A secondary MRI revealed more distal demyelination & plaques; prompting a diagnoses of relapsing-remitting MS (RRMS)[1]. The physician referred her to a private physiotherapy clinic in the community for motor control training and gait safety education.Betty's recent diagnosis has caused her considerable stress and she is fearful of losing her job, or becoming unable to support her children because of considerable fatigue and/or potential progression of gait impairment in the future. Fatigue is of great importance to Betty’s participation as a worker and a parent. Regular exercise has been cited widely in the literature as beneficial for promoting restful sleep and reducing fatigue in individuals with MS[2][3]. Therefore, education on and implementation of regular safe exercise should play a central role in Betty’s treatment plan. As for addressing Betty’s gait concerns, the National Multiple Sclerosis Society’s recommendations for managing gait impairment provide pertinent information to inform gait education and potential management of further impairment. They recommend addressing multiple aspects of gait including vision, fatigue, foot wear, and balance impairment[1]. Interestingly, in a case study conducted on a woman with similar concerns and clinical presentation, a 3 month locomotor training program involving a combination of virtual-reality based and overground balance interventions, and body-weight-supported/treadmill training twice a week, improvements were observed both at post-intervention and 2-month follow-up in gait speed, endurance and balance[4]. A challenging aspect of this case is the significant occupational modification that would likely be necessary for the patient. Graphic design requires a high level of upper extremity motor function, and without considerable workplace modification, ergonomic intervention, or additional support from the employer, continuing to pursue this line of work may prove unrealistic. For this reason the involvement of an occupational therapist and/or social worker may be warranted. Client Characteristics[edit | edit source]Betty Jackson is a 29 year old woman living with her spouse and two children in an apartment in Sudbury, Ontario. Her primary condition is RRMS. She was referred to the physiotherapy clinic by her general physician to address her motor control impairment. The physician also suggested education regarding gait and mobility aids to address Betty’s concerns about potential falls and disability. Additionally, Betty hopes to mitigate her fatigue so she can get more done at work. Examination Findings[edit | edit source]Subjective Assessment:[edit | edit source]Assessment Date: May 12, 2020 Demographics
History (Hx) of Present Illness:[edit | edit source]Medical diagnosis: Relapsing Remitting Multiple Sclerosis
Rehabilitation History: Previously attended physiotherapy regarding rehabilitation of a sprained left ankle following a sports injury approximately 10 yrs ago, but has not been to physiotherapy regarding current condition previously Past Medical History:[edit | edit source]
Current symptoms or status:
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Hobbies: Enjoys biking with her husband, and playing with her kids Occupation: Graphic designer, full-time Functional status/Activity – current and previous
Other information:[edit | edit source]Medications: Rebif[5] (self-administered subcutaneously 3x per week) Diagnostic Tests/Investigations: MRI Imaging identifying both active and inactive demyelination plaques within the corpus callosum and in the periventricular white matter Hand dominance: Right-handed Health Habits: non-smoker, 1-2 wine glasses per week, no recreational drug use Patient’s goals and concerns:
Self-reported Measures:[edit | edit source]
[7]
[10]
[13] Objective Assessment:[edit | edit source]Observation: Patient is visibly anxious, shifting weight in the seat often, and speaking quickly especially during conversation about her work, taking care of her children and how the future impairments of MS will affect this. Patient walked into the clinic independently with no gait aid. Posture: Slight forward head posture but otherwise unremarkable. Cognition: Patient is oriented to person, place, and time as well as alert. Myotomes: Within normal limits (WNL) Dermatomes: WNL Sensation Testing: WNL Active ROM
Manual muscle testing
LMN reflexes: Grossly grade 2+ (normal) Clonus: Right side= Positive, Left Side=Negative [14] Cranial Nerve Eye Movement Testing: Nystagmus noted intermittently in right eye [15] Heel-to-toe Test: 10 repetitions each side Left: WNL Right: WNL Finger-to-nose Test: 10 repetitions each side
Finger-Opposition Test:
Grip Strength-Dynamometer: RS: 20kgs, LS: 24kgs
6-minute walk test[17] (6MWT): 408m, slightly above mean for patients with MS with mild disability on EDSS[18].
Gait: Step length and step cadence slowed as patient approached end of 6MWT. Right foot noted at initial contact. Poor right sided foot clearance due to foot drop during mid-swing as patient approached end of test.[14] Spasticity: Modified Ashworth Scale[1].
(1): Slight increase in muscle tone, manifested by a catch and release or by minimal resistance at the end of the range of motion (ROM) when the affected part is moved in flexion or extension (1+): Slight increase in muscle tone, manifested by a catch, followed by minimal resistance throughout the remainder (less than half) of the ROM [19]. Nine-Hole Peg Test[20]
BERG balance scale[21] 50/56, Patient complained of feeling fatigued after item 11.
The BERG balance scale is recommended and has a high quality of evidence for outpatient patients with MS as determined in a consensus report by the American Physical Therapy Association Neurology Section Task Force[8]. Clinical Impression:[edit | edit source]Physiotherapy Diagnosis: 29yr old female diagnosed with remitting-relapsing multiple sclerosis presenting with decreased motor coordination in bilateral upper extremities especially on the right dominant side, weakness in bilateral upper extremity, fatigue, and altered gait mechanics. The symptoms and deficits experienced by the patient have caused decreased ability to independently participate in instrumental activities of daily living, decreased productivity at work, decreased balance, decreased conditioning due to fatigue, and overall anxious outlook regarding her future functioning and independence. Prognosis is positively affected by the patient’s high motivation to maintain functioning, supportive spouse, and previously high level of activity. Prognosis is negatively affected by anxious and stressful thoughts regarding future functions, and passive smoking at home which could affect cardiorespiratory outcomes. The patient will benefit from physiotherapy services to increase function of upper extremity, increased balance, manage fatigue, optimize gait pattern, and improve patient’s attitude towards the future. Problem List:
Intervention[edit | edit source]Gait Aid[edit | edit source]The use of gait aids such as canes have been indicated as a fall risk factor in individuals with MS of varying ages [23][24][25]. Considering the patient's right-sided deficits during gait (i.e., step length/cadence, foot drop, poor foot clearance) particularly after several minutes of testing, an ankle-foot orthosis (AFO) or functional electrical stimulation (FES) can be worn to mitigate the drop foot. Several studies have demonstrated that FES and AFO use can improve mobility, improve walking speed, reduce walking effort, and reduce incidence of falls, leading to improved quality of life in people with MS [26][27][28][29][30]. Bulley et al, 2014 concluded that individuals using either device (i.e., AFO or FES) reported assistance on hills/stairs, increased participation in life, greater confidence, less stress, and less mental effort when walking.[28] Home Based Intervention[edit | edit source]I). Aerobic Training: Taking into consideration the patient's hobbies, she can potentially seek out a bicycle with pedal assist (i.e., e-bike). An e-bike would allow her to pedal normally and if needed she can use the pedal assist (e.g., uphill or once fatigue begins to set in). Other methods of optimizing performance would be to have her bike at dusk or dawn to avoid the peak temperatures during the day and avoid overheating.
II). Dexterity and Upper Limb Training: The patient's occupation requires a certain degree of dexterity to manipulate different graphic design tools. The use of manipulable objects (e.g., clay, nuts/bolts, marbles) in patients with MS presenting with upper limb dexterity complications has been shown to significantly improve motor functioning, manual dexterity and hand grip strength [32][33][34]. II.a) Modeling Clay kneading: Patient kneads modelling clay with the hand forming a ball, flattening, and rolling and squeezing (5 sec) the clay (left and right hands).
II.b) Assembly: Patient assembles bolts and nuts of varying sizes using both hands.
II.c) Upper Limb Strengthening: Banded resistance training for shoulders and upper arms (Shoulder Flexion,Horizontal Abduction, Elbow Extension, Elbow Flexion).
Therapist-Guided Interventions[edit | edit source]I) Vestibular and Coordination Training (PT supervised): The patient expresses a fear of falling/tripping due to current balance deficits and is worried that her balance will continue to get worse. Specific balance and vestibular intervention have been shown to decrease risk of falls, decrease fatigue, and increase upright postural control[25][35]. Upright Postural Control: Standing with eyes open. Progress to foam surface and try with eyes closed when appropriate.
Perform 1–3 with:
II.) MS Education: There is strong evidence for incorporating education about fatigue management and energy conservation especially in conjunction to exercise programs. [35][36][37][38] Education can include topics such as;
Outcome[edit | edit source]After 8 weeks of biweekly sessions, the patient has increased finger dexterity demonstrated by a decrease of 4.6 seconds on the right and 7.1 seconds on the left during the Nine-Hole peg Test. The patient was able to purchase a used e-bike which she describes as life-changing. She is able to get on her bike and exercise without the fear of potentially getting stranded somewhere due to fatigue. The patient was able to receive funding through the Assistive Devices Program (ADP) allowing her to be fitted for an Ankle Foot Orthoses. As a result, decreased right foot drop and increased gait speed was observed. The results of the Six-Minute Walk Test also indicate a significant improvement of 79 meters from baseline (total 487 meters). Furthermore, the patient reports feeling more confident during ambulation. The patient demonstrated some other improvements according to the outcome measures re-administered during the last assessment. For the Upper Extremity Functional Scale (UEFS) she scored a 70/80 indicating improvement in upper extremity function. For the Fatigue Scale for Cognitive and Motor Function her total score of 36/100, (14/50 on cognitive fatigue and 22/50 on the motor fatigue) also indicates improvement. The MSIS-29 showed similar improvement, with a reduction of the physical impact score from 23.75 to 16.25, and the psychological impact score reduced to 25, from 30.56 prior. The patient has met all goals (i.e., increase balance, decrease fatigue, increase upper limb function and dexterity) and is ready to be discharged and seen on an “as needed” basis for exercise progression. The importance of continuing to be physically active and monitoring fatigue was emphasized to the patient during the last appointment. Discussion[edit | edit source]This case study investigates the clinical presentation of Betty, a young, active female patient diagnosed with RRMS. Betty initially presented to her family physician on two occasions about 10 months apart with symptoms of fatigue, impaired upper extremity function, and vision impairment. Subsequent to acquisition of MRI findings of demyelination plaques, Betty was diagnosed with RRMS by her physician and referred to physiotherapy for functional rehabilitation and management. Upon subjective and objective examination, the physiotherapist team was able to work with Betty to create a problem list, including impaired dexterity, coordination, balance, and fatigue, affecting her activity, participation, and occupation. Addressing occupation-related dysfunction using a biopsychosocial approach is paramount, as patients with MS may often experience negative outcomes and mental debilitation due to the complex nature of the disease[40]. For Betty, this included a comprehensive treatment plan including coordination, postural/balance, dexterity, aerobic, and gait aid training, which were monitored by various self-reported and clinician-reported outcome measures. Furthermore, implementation of self-management interventions such as education and activity modification (i.e., e-bike) is important due to the progressive nature of MS. The broader implications of this case suggest the benefit of a multi-modal approach to both assessment and treatment for patients with mild RRMS. A comprehensive subjective and objective assessment to fully understand a patient's history, functional capabilities, and goals, are imperative in developing an appropriate treatment plan[41]. Utilization of outcome measures, applying a biopsychosocial model to treatment, and educating patients to self-monitor can reduce the negative impact that MS has on both physical and mental function[42]. However, due to the progressive nature of the disease, rehabilitation in severe cases becomes increasingly more complex [41]. Literature for more severe presentation of the disease is lacking, and thus future studies should aim to research the implications of severe MS. Self study questions[edit | edit source]Follow the hyperlinks to check your answer In regard to multiple sclerosis, specific balance and vestibular intervention has evidence showing that it can: a.) Decrease fatigue b.) Increase anticipatory posture control c.) Decrease fear of falling d.) All of the above Choose the CORRECT statement - Multiple sclerosis is a neurological condition characterized by inflammation and demyelination: a.) With excessive fatigue lasting several years b.) With unpredictability in all aspects of the disease c.) Across time and locations within the CNS d.) That has little effect on a patients day to day life References[edit | edit source]
What is the assessment for MS?The physical exam is the most important tool for assessing MS relapse. This involves assessing vital signs, which may reveal alterations in temperature, blood pressure, and heart rate. A thorough neurological exam should include assessment of vision, strength, sensation, gait, and coordination.
Which assessment findings are support the diagnosis of MS?In order to make a diagnosis of MS, the physician must: Find evidence of damage in at least two separate areas of the central nervous system (CNS), which includes the brain, spinal cord and optic nerves AND. Find evidence that the damage occurred at different points in time AND. Rule out all other possible diagnoses.
What would you expect from a patient with multiple sclerosis?Multiple sclerosis (MS) is a disease of the central nervous system that can affect the brain, spinal cord and optic nerves. Common symptoms include fatigue, bladder and bowel problems, sexual problems, pain, cognitive and mood changes such as depression, muscular changes and visual changes.
Which of the following signs and symptoms is most common in MS?The most common symptoms of MS include fatigue, numbness and tingling, blurred vision, double vision, weakness, poor coordination, imbalance, pain, depression and problems with memory and concentration. Less commonly MS may cause tremor, paralysis and blindness.
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