Which of the following best explains the process occurring between .1.2 in Figure 3?

(melanin synthesis pt 1)
In mammals, the dark color of skin, hair, and eyes is due to a pigment called melanin. Melanin is produced by specialized skin cells called melanocytes. The melanin is then transferred to other skin cells called keratinocytes. Melanocytes synthesize melanin in a multistep metabolic pathway (Figure 1). The amount of melanin produced is dependent on the amount of the enzymes TYR, TRP2, and TRP1 present inside melanocytes.

Figure 1. Melanin synthesis pathway

The peptide hormone α-melanocyte stimulating hormone (α-MSH) activates a signal transduction pathway leading to the activation of MITF. MITF is a transcription factor that increases the expression of the TYR, TRP2, and TRP1 genes (Figure 2).

Figure 2. Activation of melanin synthesis genes in melanocytes

Some mammals increase melanin production in response to ultraviolet (UV) radiation. The UV radiation causes damage to DNA in keratinocytes, which activates the p53 protein. p53 increases the expression of the POMC gene. The POMC protein is then cleaved to produce α-MSH. The keratinocytes secrete α-MSH, which signals nearby melanocytes. The increased melanin absorbs UV radiation, reducing further DNA damage

Figure 3. Production of α-MSH in keratinocytes in response to UV radiation

Which of the following claims about the TYR, TRP2, and TRP1 mammalian genes is most likely to be accurate?

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